China (Mainland)
manufacture GLP-1 (7-37) Acetate CAS NO.106612-94-6
- FOB Price: USD: 10.00-20.00 /Gram Get Latest Price
- Min.Order: 10 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
Top Grade(1-10)Gram Top Grade(10-50)Gram
- Product Details
Keywords
- GLP-1 (7-37) Acetate powder
- GLP-1 (7-37) Acetate raw powder
- GLP-1 (7-37) Acetate Injection
Quick Details
- ProName: manufacture GLP-1 (7-37) Acetate
- CasNo: 106612-94-6
- Molecular Formula: 106612-94-6
- Appearance: White to off white powder
- Application: Pharmaceutical
- DeliveryTime: Within 7 working days
- PackAge: plastic tube/vials
- Port: Shanghai
- ProductionCapacity: 1000 Gram/Week
- Purity: ≥98%
- Storage: Store in a cool dry place and keep awa...
- Transportation: EMS,TNT,DHL
- LimitNum: 10 Gram
- Moisture Content: 0
- Impurity: 0
- Certification: GMP
- Molecular: 1031.17
- Specification: iu mg g kg
- Customized: Customized
Superiority
Superiority
1.As a professional production leading factory & lab in China in pharmaceutical area of 15 years, our market to USA, Australia, Middle East, Germany, Spain, UK, and so on other country. What’s more, good feedback from our customers. We had Established long friendly relations of cooperation.
2.High quality, best price, firstclass service, high successful delivery rate.
3.We have stock, so we can delivery quickly at the very day when receive the payment.
4.We will never sell, solicit,or give your information to any third parties. All transactions are confidential.Your satisfaction is guaranteed,as long as you have dissatisfaction,we will show our biggest sincerity and patience to solve problems.
5.We have the special way can ship 50 grams to 50kg products at a time. We can offer the melting powder into liquid service.And ship the liquid in the special bottles. According to your request and the quantity what you buy, we have several packaging methods for your choice. safety and quick shipping to you.
6.We can do ,TT and Money Gram wire transfer payment term.
Details
Glucagon-like peptide 1 (GLP-1) is an secretagogue synthesized in the intestine and released in response to meal ingestion. It is secreted primarily in two forms, GLP-1-(7-37) and GLP-1-(7-36)NH(2), both of which bind to a specific GLP-1 receptor (GLP-1r) on the pancreatic beta-cell and augment glucose-stimulated secretion. Once secreted, GLP-1-(7-36)NH(2) is rapidly metabolized to GLP-1-(9-36)NH(2), which is the predominant form of GLP-1 in postprandial plasma because of its relatively slower clearance. Although no clear biological role for GLP-1-(9-36)NH(2) in humans has been identified, recent studies in animals suggest two potential effects: to antagonize the effects of intact GLP-1 and to promote glucose disappearance in peripheral tissues. In the studies reported here we compared the independent effects of GLP-1-(7-36)NH(2), GLP-1-(7-37), and GLP-1-(9-36)NH(2) on parameters of iv glucose tolerance and determined whether GLP-1-(9-36)NH(2) inhibits the insulinotropic actions of GLP-1. Ten healthy subjects underwent 4 separate frequently sampled iv glucose tolerance tests during infusions of GLP-1-(7-37), GLP-1-(7-36)NH(2), GLP-1-(9-36)NH(2), or saline. Results from the iv glucose tolerance test were used to obtain indexes of beta-cell function (acute response to glucose) and iv glucose tolerance (glucose disappearance constant), and the minimal model of glucose kinetics was used to obtain indexes of glucose effectiveness and sensitivity. Compared with control studies, both GLP-1-(7-36)NH(2) and GLP-1-(7-37) significantly increased acute response to glucose, glucose disappearance constant, glucose effectiveness, and glucose effectiveness at zero insulin, but did not change the sensitivity index. In contrast, none of the parameters of glucose tolerance was measurably affected by GLP-1-(9-36) amide. In a second set of experiments, 10 healthy subjects had glucose-stimulated secretion measured during an infusion of GLP-1-(7-36)NH(2) alone or with a simultaneous infusion of GLP-1-(9-36)NH(2) that increased plasma levels approximately 10-fold over those produced by unmetabolized GLP-1. Augmentation of glucose-stimulated secretion by GLP-1-(7-36)NH(2) was not altered by the coadministration of GLP-1-(9-36)NH(2). Based on these results we conclude that GLP-1-(9-36)NH(2) does not regulate release or glucose metabolism in healthy humans.
| Product Name | GLP-1 (7-37) Acetate |
| Place of origin | China |
| Routine use of storage | 2-8ºC |
| Cycle-time | 3-7days |
| Purity | 98%min |
| Brand Name | Filter |
| Valid Date | 2years |
| Delivery Date | In 7 days |