Growth Hormone GHRP-2 for Weight Loss CAS NO.158861-67-7

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Growth Hormone GHRP-2 for Chemical Research 

------Product Description------

It is important to know that GHRP-2 does not relate to any Growth Hormone Releasing Hormones (GHRH) peptides such asSermorelin and CJC-1295 because it acts on different receptors. However, greater results occurred when administered in conjunction with a Growth Hormone Releasing Hormone (GHRH) such as Modified GRF 1-29 or CJC-1295 DAC. Naturally, these GHRP-2 peptide receptors interact with a hormone called ghrelin. Growth hormone releasing peptide 2 is a commercially synthesized, non-natural super-analog of GHRP-6 which is capable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol (Arvat et al. 1997). It is also a synthetic agonist of ghrelin that is binding with the growth hormone (GH) secretagogue receptor. GHRP-2 has been shown to affect and induce growth hormone secretion. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to this peptide .

------Comparing GHRP-2 and GHRP-6------
GHRP-2 is a 2nd generation GHRP just behind GHRP-6. Compared to GHRP-6, GHRP-2 is considered to be much more superior in terms of growth hormone stimulation because over longer periods of time it maintains maximum elevations in Growth Hormone. GHRP-2 has shown to increase IGF-1 levels (Insulinlike Growth Factor 1), and even greater results happen when used with Growth Hormone Releasing Hormone (GHRH). It has a short half life with peak concentrations occurring around 15 minutes but not longer than 60 minutes. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to the high-amplitude pulsation from the GHRP-2. GHRP-2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or somatotrope by other means. Unlike ghrelin, GHRP-2 is not lipogenic which means that it does not induce fat storage. Although ghrelin plays a large role in hunger, GHRP-2 as an analog of ghrelin does not increase appetite significantly.

------How does it work------

The single polypeptide chain composed of six amino acids is a growth hormone releasing peptide.  This hexapeptide not only functions to stimulate ghrelin release, but it also works to correct production of low level growth hormone.  Simply put, GHRP-2 is perfectly designed with the intention of releasing human growth hormone from the pituitary gland.  These mechanisms have been shown to promote lean body gains in lean body individuals.  Since GHRP-2 is a ghrelin agonist, it helps to promote the secretion of human growth hormone in a two fold process. For one, it acts to boost growth hormone through amplification of the transduction pathway.  In addition, it suppresses the action of somatostatin (a hormone which limits the release of growth hormone).  These actions make GHRP-2 a perfect option to increase endogenous growth hormone levels.

------Dosage and Usage------

Just like the other peptides we have covered so far, GHRP-2 comes as a lyophilized powder.  It must be stored in a cool dry place and should be reconstituted using bacteriostatic water or sodium chloride meant for injection.  Once the peptide has been reconstituted, GHRP-2 must be kept in a cold storage like the refrigerator until ready for use.  GHRP-2 can be taken in high dosages, if needed; however, it is still unclear how effective these high doses are.  Normally, GHRP-2 will be used 2-3 times a day at around 100mcg-300mcg per injection.  As with other GHRP's, it's highly advisable to also use a GHRH in order maximize the effectiveness of the pulse wave combination in accessing the pituitary pathway to release growth hormone.

-----Company Info------ 

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